DOI: 10.21276/ajptr
Mon, 22 Jul 2019

Solubility Enhancement of Valsartan Using Solid Dispersion Technique With Novel Carriers

M. Balakrishnaiah1, 2*, V. Rama Mohan Gupta2

1.Acharya    Nagarjuna University, Nagarjuna nagar, Guntur-522 510, A.P, India

2.Pulla Reddy Institute of Pharmacy, Narsapur road, Medak-502 313, TS, India


Solubility is an important physicochemical factor affecting absorption of drug and its therapeutic effectiveness. Drugs having poor aqueous solubility present one of the major confronts better absorption for good bioavailability of such drugs. The purpose of this study was to prepare and characterize solid dispersions of the poorly water soluble antihypertensive agent valsartan with water soluble carriers such as Kolliphor P 407, Kolliphor P 188, Kolliwax GMS II, Kolliphor HS15, HPMC AS and Soluplus in proportions viz. 1:1, 1:3, 1:5 (Drug: Carrier) with addition of 2% SLS to improve its aqueous solubility and rate of dissolution by solvent evaporation technique. All the formulations showed marked improvement in the solubility behavior and improved drug release. From all the formulations  SD6 was found to be optimized formulation  using soluplus as carrier based on the solubility and dissolution studies. The results obtained showed that the aqueous solubility and rate of dissolution was significantly improved when formulated in solid dispersion as compare to pure drug.

Keywords: Valsartan, solid dispersions, soluplus, aqueous solubility


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