Tue, 21 Nov 2017

Gastro Protective and anti oxidant activity of Cow urine betel vine extract in ethanol induced Peptic ulcer in Rats

N.B.Sridharamurthy1*, B.A. Sowmya1,  Manasa MM2

1.Department of Pharmacology, School of Pharmaceutical Sciences, Dayananda Sagar University, Kumarswamy layout, Bangalore-78, Karnataka


ABSTRACT

The present study was designed to investigate the antioxidant and gastro-protective potential of Cow urine betel vine extract. Antioxidant and gastro-protective activity was evaluated by using ethanol induced ulcer model; the animals were fed with Cow urine betel vine extract at the dose of 250 and 500mg/kg b.w orally for a period of 14 days. The pretreated extract reduced the gastric ulcers in a dose dependent manner which was determined by measuring the ulcer index and with marked attenuation in the levels of oxidative stress enzymes like SOD, LPO and CAT. Also Cow urine betel vine  increased the gastric mucous content in the selected ulcer model.

Keywords: Antioxidant activity, antiulcer activity and ethanol induced ulcer, Cow urine betel vine extract. 


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