Tue, 21 Nov 2017

Bioactive secondary metabolites of endophytic fungi from three medicinal plants in Nigeria

Abass Tolulope  R1, Adeleye Isaac A1* ,, Adongbede Erute M2,  Adekunle Adedotun A1, Seriki Abiodun.T1

1.Department  of  Microbiology , University of Lagos, Akoka, Lagos State, Nigeria

2. Department of Botany, University of Lagos, Akoka, Lagos State, Nigeria


ABSTRACT

Endophytic fungi are potential sources of bioactive secondary metabolites that can be exploited for therapeutic purposes. Our study was aimed to identify bioactive secondary metabolites from crude extracts of endophytic fungi of three popular medicinal plants (Alstonia boonei- Ahun, Enantia chlorantha- Awopa and Kigelia africana- Pandoro) that have ethnobotanical history in Nigeria. The endophytic fungi were isolated from the stem barks of the plants using standard procedures. They were later fermented in broth culture, and the extract from the cell free broth of each of the fungi was subjected to Gas-Chromatography Mass-Spectrophotometry (GCMS). The results showed that, twenty-one different compounds were characterised from Aspergillus niger, Macrophomina sp, Trichoderma sp. and Penicillium species. The bioactive compounds include; Griseofulvin, Cinnamic acids, Penicillin, Coumarin, Cubenol, Erythritol among others. The presence of these compounds may contribute to the therapeutic properties of the plants.

Keywords: Endophytic fungi, bioactive secondary metabolites, medicinal plant, GC/MS


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