Tue, 21 Nov 2017

Ethanol extract of Ficus Racemosa l. Stem bark moderates diabetic and diarrhoeal activities in wistar rats

S. Mazumdar1*, R. Akter1

1. Pharmacology Research Division, BCSIR Laboratories, Chittagong, Chittagong-4220, Bangladesh.


ABSTRACT

The present study scrutinizes the antidiabetic and the antidiarrhoeal effects of ethanolic extracts of  Ficus racemosa L. stem barks (EEFB) in Wistar rats. Oral glucose tolerance test (OGTT) model and alloxan induced diabetic model (AIDM) were performed to assess antidiabetic activity of EEFB at doses of 750mg/kg, 500 mg/kg and 250 mg/kg, and 2g/ kg respectively. For antidiarrhoeal effects of EEFB, castor oil-induced diarrhoeal (COID) model and gastrointestinal motility test with barium sulphate milk (BSM) model were also assessed at doses of 750 mg/kg and 500 mg/kg, and 250mg/kg respectively. Administration of EEFB resulted low blood glucose levels in OGTT model at doses 750 mg/kg and 500 mg/kg significantly (P<0.01). However, dose at 250 mg/kg also showed positive result (P<0.05) of the mentioned same antidiabetic model. In AIDM, Wistar rats showed worthy result at 2g/kg dose (P<0.001). After administration of EEFB at doses 750 mg/kg and 500 mg/kg inhibited significantly positive in COID model at P<0.01and P<0.05 respectively. However, at the dose of 250 mg/kg illustrated positive but not significant result in BSM model.

Keywords: Ficus racemosa, bark extract, antidiabetic, antidiarrhoea and Wistar rats

 

 

 

 

 


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