DOI: 10.21276/ajptr
Fri, 24 May 2019

Design, Synthesis, Characterization and Anti-Microbial Screening of Some Novel Thiocarbamidochalcones

D. T. Tayade1, S. A. Waghmare2*

1.Department of Chemistry, Govt. Vidharbh Institute of Science & Humanities, Amravati- 444 604 (M.S.) India

2.Department of Chemistry, Ghulam Nabi Azad College, Barshitakli Dist. Akola-444 401(M.S.) India


Interactions of (2E)-1-(4-chlorophenyl)-3-(3,4 dimethoxyphenyl)prop-2-en-1-one with various substituted thioureas such as thiourea, N-phenylthiourea, 2-chlorophenylthiourea, 3-chlorophenylthiourea and 4-chlorophenylthiourea in presence of isopropanol as a medium. The products isolated in these reactions were characterized on the basis of conventional elemental analysis, chemical characteristics and spectral data. All the synthesized compounds screened against various microorganisms such as gram positive Staphylococcus aureus, gram-negative Escherichia coli. Ciprofloxacin was used as a standard drug for the antimicrobial screening.

Keywords: (2E)-1-(4-chlorophenyl)-3-(3,4 dimethoxyphenyl)prop-2-en-1-one, substituted thioureas, isopropanol, antibacterial, ciprofloxin etc.

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