Tue, 21 Nov 2017

Preparation and Evaluation of Oral Stomach Specific In Situ Gelling Emulsion of Piroxicam

Seema Desai*1, Sudha Rathod1, Priyanka chauhan1, Ankita Dhumal1

1: Oriental college of pharmacy, sanpada navi Mumbai 400705


ABSTRACT

The aim of the present study is to minimize the local gastrointestinal irritation which is one of the major side effects of Piroxicam (PR) by the formulation  oral  stomach specific in situ gelling emulsion ingestion by kinetic control of drug release. Material and method: In situ emulgel were prepared by using castor oil as oil phase ,tween 80 and span 80 as emulsifiers, sodium alginate was used as gelling agent,  xanthan gum was used as release retardant ,calcium carbonate was used as cross linking agent, pH triggered ionic gelation is the mechanism involved in the present study. Various evaluation tests were done for all formulations Results: Formulation F9 containing 2.5% of sodium alginate, 2 % of CaCO3, 1 % of sodium bicarbonate and 0.8% of Xanthan gum was selected as optimized batch based on  Q10 86.02±0.17 %, floating time 122.15±2.47 sec and drug content 91.86±1.02 %. The release pattern of drug was found to follow Korsemeyer and Highuchi model. The DSC study exposed that there was no incompatibility. Pharmacodynamic study on Wistar rats were showed significant anti inflammatory and anti arthritic activity of the optimized formulation. Further, in vivo toxicity studies carried out in wistar rats revealed no signs of gastric ulceration upon prolonged dosing. Conclusion: It was concluded that the oral stomach specific In situ gelling emulsion of piroxicam could be an effective dosage form which minimize the gastric irritation by coating drug with castor oil and remains buoyant and control the drug release for 24hrs.

Keywords: In situ gelling emulsion, Piroxicam, Castor oil, Gastric retention, In vitro release, Gastric irritations.


[PDF]  Viewed: 532  Downloaded: 126
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter