DOI: 10.21276/ajptr
Mon, 22 Jul 2019

Efficient synthesis of antimicrobial active annulated uracil Derivatives

Umer D. Rather1, Ajmal R. Bhat2*, Imtiyaz R. Parrey3

1. Senior Assistant Professor,  Department of Chemistry, Govt. P.G. College Bhadarwah Jammu-182222, India

2.Department of Chemistry, Islamic University of science & technology Kashmir-192122, India

3. Department of chemistry, Jamia Millia Islamia, New Delhi- India


1, 4-diazabicyclo [2.2.2] octane (DABCO) as an efficient organocatalyst were used for synthesis of annulated uracil derivatives via one-pot three component condensation reactions of substituted aromatic aldehydes, malononitrile and barbituric acid in aqueous ethanol carried at NTP. This is rapid, efficient synthetic route with several advantages viz; operational simplicity, mild reaction conditions, high yields of the biological active products, uses less toxic solvents and cheap catalyst. The synthesized products were screened for antimicrobial activity. Therefore annulated uracil derivatives   are excellent antimicrobial agents for globally alarming drug resistance issues in clinically used therapeutics.

Keywords:   Multi-component,   Pyrano [2, 3-d] pyrimidine, DABCO, Antimicrobial activity


[PDF]   Viewed: 780   Downloaded: 94
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter