Tue, 21 Nov 2017

Protective Role of Nobiletin on Antioxidants Activity and Xenobiotic Metabolizing Enzymes against Benzo(a)Pyrene Induced Lung Cancer and in Swiss Albino Mice

Kasthuri Kannayiram1, Dhivya sathyamoorthy1, Selvaraj sundramoorthy1, Sakthisekaran Dhanapal1*

1. Department of Medical Biochemistry, University of Madras, Taramani campus, Chennai 600113.


ABSTRACT

About 1,685,210 new cancer cases are expected to be diagnosed in 2016. Superoxide dismutase protect against oxygen free radicals by catalyzing the removal of superoxide radicals  hydrogen peroxide mediated LPO. B(a)P induces the oxidation of mitochondrial NADPH.  An increase in the NADP+/NADPH ratio, the low availability of substrate NADPH may be responsible for the decrease in the activity of GR. Reduced glutathione, vitamin C and α-tocopherol comprise the non-enzymatic antioxidant components which protects the cells against the deleterious effects of the free radicals. Phase I & II metabolizing enzymes plays an important role in the detoxification of electrophilic toxicants and their induction protects against carcinogenesis and mutagenesis.

Keywords : Benzo(a)Pyrene, Nobiletin, Detoxification, Antioxidants

 


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