Tue, 21 Nov 2017

Synthesis and Characterization of novel Formamidines, benzothiazolyl formamidines and formimidic acid alkyl ester as potential antimicrobial agent

Varsha S. Zade1* , Gajanan V. Korpe1

1.P. G. Department of Chemistry, Shri Shivaji College, Akola 444003 (M.S.) India


ABSTRACT

Formamidines, Thiazoles, dithiazolidines, thiadiazines and other ring system derivatives have a long history of applications in pharmaceutical and agrochemical industries. Our interest in the chemistry of the formamidine  nucleus and its derivatives prompted us to explore the synthesis of 1-hepta-O-acetyl- β-D-lactopyranosyl-3-H/Aryl formamidines, N-hepta-O-acetyl- β-D-lactopyranosyl-N’-benzothiozolyl formamidines and N-hepta-O-acetyl-β-D–lactopyranosyl formimidic acid alkyl esters by reductive desulphurization of 1-hepta-O-acetyl- β-D–lactopyranosyl–H / aryl thiocarbamides, 1-hepta-O-acetyl-β-D-lactopyranosyl-3-[2-N-substituted benzothiazolyl] thiocarbamides and 1-hepta-O-acetyl-β-D–lactopyranosyl-O-alkyl thiocarbamates respectively using Raney Nickel. The identities of these newly synthesized derivatives have been established on the basis of chemical transformations and IR, 1H NMR and Mass spectral studies. The title compounds have been assayed for their biological activity against gram-positive as well as gram negative microorganisms. These compounds show most promising activity towards these micro-organisms.

Keywords: Synthesis, Lactosylated formamidines and its derivatives, Antimicrobial activity.


[PDF]  Viewed: 325  Downloaded: 77
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter