DOI: 10.21276/ajptr
Sun, 21 Jul 2019

Synthesis and Characterization of novel Formamidines, benzothiazolyl formamidines and formimidic acid alkyl ester as potential antimicrobial agent

Varsha S. Zade1* , Gajanan V. Korpe1

1.P. G. Department of Chemistry, Shri Shivaji College, Akola 444003 (M.S.) India


Formamidines, Thiazoles, dithiazolidines, thiadiazines and other ring system derivatives have a long history of applications in pharmaceutical and agrochemical industries. Our interest in the chemistry of the formamidine  nucleus and its derivatives prompted us to explore the synthesis of 1-hepta-O-acetyl- β-D-lactopyranosyl-3-H/Aryl formamidines, N-hepta-O-acetyl- β-D-lactopyranosyl-N’-benzothiozolyl formamidines and N-hepta-O-acetyl-β-D–lactopyranosyl formimidic acid alkyl esters by reductive desulphurization of 1-hepta-O-acetyl- β-D–lactopyranosyl–H / aryl thiocarbamides, 1-hepta-O-acetyl-β-D-lactopyranosyl-3-[2-N-substituted benzothiazolyl] thiocarbamides and 1-hepta-O-acetyl-β-D–lactopyranosyl-O-alkyl thiocarbamates respectively using Raney Nickel. The identities of these newly synthesized derivatives have been established on the basis of chemical transformations and IR, 1H NMR and Mass spectral studies. The title compounds have been assayed for their biological activity against gram-positive as well as gram negative microorganisms. These compounds show most promising activity towards these micro-organisms.

Keywords: Synthesis, Lactosylated formamidines and its derivatives, Antimicrobial activity.

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