DOI: 10.21276/ajptr
Mon, 27 May 2019

Formulation and Evaluation of Lornoxicam Topical Gel

Shereen A. Eladawy1, Amal S. M. Abu El-Enin1, Soha A. Ismail2, Eman R. Mishrif2*

1.Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy,

Al-Azhar University, Nasr City, Cairo, Egypt.

2. National Organization for Drug Control and Research, El-Dokki, Egypt.


The aim of this work is to improve the anti-inflammatory activity of Lornoxicam through incorporating it in a topical gel using different polymers as Carbopol 934, Sodium carboxy methylcellulose or Sodium alginate. Various penetration enhancers (Glycerin, Polyethylene glycol or Sorbitol) were used with objective of enhancement in the percutaneous permeation of the drug. Formulations were evaluated for pH, drug content, rheological properties, spreadability, in-vitro drug release in phosphate buffer (pH 6.5) and permeation study through cellulose membrane. Anti-inflammatory activity of Lornoxicam gel was studied in rats by carrageenan induced paw edema method and compared with the commercial formulation (Feldene® gel). Considering physical properties, in-vitro release and in-vitro permeation studies, FS1 (Lornoxicam gel containing 1% Carbopol with 10% Sorbitol as penetration enhancer) was the best formula among the studied formulations, this formula also exhibited significantly higher anti-inflammatory activity in rats compared to Feldene® gel.

Keywords: Lornoxicam; Topical gel; Penetration enhancers; In-vitro drug diffusion study; Anti-inflammatory activity.

[PDF]   Viewed: 1632   Downloaded: 273
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter