Mon, 18 Dec 2017

An Effective Novel Strategy of Combined Plants Extract for the Treatment of Parkinson's Disease

Parwez Alam1*, Jyoti Gupta2, Seema Firdouse1

1. Singhania University, Pacheri Bari, Jhunjhunu- 333515, Rajasthan, India.

2. MVN University, Palwal-121105, Haryana, India.


ABSTRACT

The aim of present study was an effective novel strategy of combined plants extract for the treatment of Parkinson’s disease, using Amla Withania and Tulsi extract in different ratio. The extracts were prepared by using solvents like 60% ethanol for Amla fruit, 50% ethanol for Withania root and pure ethanol for Tulsi aerial part. Haloperidol was used to induce catalepsy and Akinesia. The ability of these combined extracts in inhibition of haloperidol-induced catalepsy and Akinesia in rodent models of Parkinsonian symptoms also Motor co-ordination test was conducted using a rota rod apparatus. It was found that treatment with the extract significantly reduced catalepsy according to dose.  In the second experiment haloperidol was used to suppress locomotor activity in test. Treatment with extract significantly increased locomotion reduced by haloperidol according to dose.

Keywords: Amla fruits, Withania roots, Tulsi aerial parts, Extracts, Parkinson’s disease.


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