Mon, 18 Dec 2017

Flavonoids insulinogeneic action” may be “A promising alternative for diabetes” management

Nandhakumar Loganathan1*, Mohan Sellappan2

1. Department of Pharmacy, Shri Jagadish Prasad Jhabharmal Tibrewala University, Jhunjhunu, Rajasthan, India.

2. Faculty of Pharmacy, Karpagam college of Pharmacy, Coimbatore, Tamilnadu, India.


ABSTRACT

Flavonoids (polyphenols) do have their entire sort of insulin inception like action genetically on β- cells of islets of langerhans, and then decline blood glucose level to an optimum. Researches over few flavonoids like diosmin, fisetin, morin, hesperidin, naringenin etc., perceived to have insulin secreting and utilizing action in pancreatic cells and peripheral tissues glucose respectively. For this reason only, exploitation of these polyphenols in treating diabetes is highly beneficial, and it is rarely pronounced on its experimental front in recent times. Though vincristine (vincristine tablets) a natural alkaloid obtained from periwinkle plant has been contemporary, in place for treating Hodgkin’s lymphoma clinically, and found to be the most successful modern medicine. Similarly, may be flavonoids do have a very huge potential, for treating diabetes clinically with therapeutic significance, if the area of interest of flavonoids focused on diabetic management. At the same time as, fundamental research performed on these flavonoids suggests that, the flavonoids mechanisms of action are manifold. Typically mechanisms of flavonoids on glucose metabolisms are insulin uptake in skeletal muscles, regulating rate-limiting enzymes in carbohydrate metabolic pathways, insulin mimetic and secretagogue action. Hence, in this hypothesis we suggest that, managing diabetes and its complications with one or more flavonoids as a novel dosage form, having various facets of glucose metabolism regulation with regards to insulin secretion, mimic and utilization, as it would be a novel approach in treating diabetes.

Keywords: Flavonoids, insulinogenic action, diabetes, treatment for diabetes and dosages.


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