DOI: 10.21276/ajptr
Mon, 20 May 2019

Synthesis and Biological Studies of 4-(4-chloro-1-hydroxynaphthalen-2-YL)-6- aryl-5,6-dihydropyrimidin-2(1H)-one

V.M.Sherekar1 , S.E.Bhandarkar1* 

1. Govt.Vidarbha Institute of Science and Humanities, Amravati- 444604,(M.S.) (Cell : 9096112804)


1-(4- chloro -1-hydroxynaphthalen-2-yl)-ethanone were prepared by refluxing 4- chloro -naphthalen-1-ol with  glacial acetic acid in presence of fused ZnCl2 then 1-(4- chloro -1-hydroxynaphthalen-2yl)-2-aryl-prop-2-en-1-one were synthesized  from  1-(4- chloro -1-hydroxynaphthalen-2-yl)-ethanones by condensing it with aromatic aldehydes. 1-(4- chloro -1-hydroxy-naphthalen-2-yl)-3-aryl-prop-2-en-1-ones, urea and concentrated HCl in DMF were added and refluxed. Cool & pour in crushed ice, it was then treated with cold NH4OH solution to get titled compounds. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. All of these titled synthesized compounds are found to posses excellent antimicrobial activities.

Keywords: Synthesis, Biological Studies, antimicrobial study, 4-(Chloro-Naphthalene-2-Yl)-6-Aryl-5, 6- Dihydropyrimidin-2(1h)-One.

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