Mon, 18 Dec 2017

Antilithiatic activity of Grewia asiatica by Sodium oxalate induced Urolithiatic model

P. Veeresh Babu1*, M. Vamsi krishna1, M. Ganga Raju1, P. Venkanna1

1.Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana


ABSTRACT

Grewia asiatica is a plant commonly used as a traditional herbal medicine and possesses the wide range of pharmacological applications. The present study investigated the antilithiatic activity of an ethanolic leaf extract of Grewia asiatica Linn (EEGA). Sodium oxalate (7 mg/100 gm i.p) administration resulted in hyperoxaluria as well as increased urinary volume and its pH. EEGA (200 & 400 mg/kg) was given orally in curative and preventive regimens over a period of 14 days. Supplementation with EEGA significantly (p<0.05) restored urea, uric acid, creatinine, sodium, potassium, chloride, volume of urine and pH levels. The preventive regimen was found to be better than the curative regimen. The results were comparable with the standard drug, Cystone (500 mg/kg). The presence of triterpenoids, flavonoids and saponins in extract might be responsible for significant antilithiatic activity of the plant. These findings affirm assertions made regarding the effectiveness of the extract of this plant against urinary pathologies in the Indian folk medicine.

Keywords: Grewia asiatica, Sodium oxalate, Cystone, Hyperoxaluria


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