Wed, 22 Nov 2017

Review on Anti-Fungal Film Forming Hydrogel

Linsha Paul T1*, K. Krishnakumar2, Dineshkumar B2, Smitha K Nair2, Sandhya S1*

1.Dept. of Pharmaceutics, St James College of Pharmaceutical Sciences, Chalakudy, Kerala

2. St James Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy, Kerala


ABSTRACT

Anti-fungal agents like flucanazole, itraconazole, ketoconazole, clotrimazole etc. are used to treat various superficial and systemic fungal infections. Oral and parenteral administration of the antifungal drugs are associated with various side effects including headache, nausea, vomiting, abdominal pain, gastric ulceration and bleeding. Hepatic and renal toxicity was also observed in patients on high and prolonged use of drugs. Film forming hydrogels are the dosage form for the topical delivery of drugs and it can bypass the side effects related to the conventional dosage forms and can provide effective topical release of the drugs. These film forming gels are novel approach for providing sustained release with increased residence time, therapeutic effect and patient comfort.

Keywords:  Antifungal agents, film forming hydrogel, topical drug delivery.


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