Wed, 22 Nov 2017

Estimation of IsoAmyl-2-CyanoAcrylate Purity by Gas Chromatography

B.C.K.Reddy 1, T.Srinivasarao2*, Latika Lokesh kumar3, G.Naresh Reddy4

1,Head of Formulation & Analytical Research and Development, Concord Drugs Limited, Hyderabad-501511, India. *

2. AAR Mahaveer Engineering College, Hyderabad-500005, India.

3. Hindu College of Pharmacy, Guntur-522002, India.

4.. AAR Mahaveer Engineering College, Hyderabad-500005, India


ABSTRACT

Isoamyl-2-cyanoacrylate is a non-toxic, bio-compatible, haemostatic and bacteria static monomeric component in nature. But in presence of moisture it gets converted into polymer. It is used as tissue Bio-adhesive; it is an alternative to suturing in medical and cosmetic surgeries. It is an inert material solidifies rapidly in alkaline media and slowly solidifies in acidic media within 5-10 seconds. It has a tendency of rapid wound closure with minimal scarring and reduces the subsequent infection. It is less traumatic and more efficient, precise and safe. It effectively replaces the conventional wound closure procedures. It is an active component in brand name “Amcrylate” is manufactured and promoted by” Concord drugs Limited” Hyderabad. The analytical gas chromatographic method is developed for the estimation of purity of isoamyl-2-cyanoacrylate, procedure as follows.

Keywords: Iso Amyl 2-CyanoAcrylate, Bio-Adhesive, Suture less Skin closure in Pediatric day-care surgery, Amcrylate Purity Analysis by Gas-Chromatography.


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