Wed, 22 Nov 2017

Synthesis, Characterization of Some Novel Schiff bases Derived from Imidazo [1, 2-a] pyridines for Anti-inflammatory and Antibacterial Activities

Mood Sikender1, Ameena Begum1, Rishika Unyala1, Chirra Hepsibha1, B.Madhava Reddy1, V.Harinadha Babu1*

1.Department of Medicinal Chemistry, G.Pulla Reddy College Of Pharmacy, Mehdipatnam, Hyderabad-500028


ABSTRACT

Imidazo [1, 2-a] pyridine based Schiff bases have been synthesized by condensing different 3-aryl-5-methyl isoxazole hydrazides with 2-aryl imidazo [1, 2-a] pyridine carbaldehydes by following hybridization approach. The structures of newly synthesized Schiff bases have been characterized by spectral data and elemental analysis. In In vivo anti-inflammatory screening, compounds 4b & 4f showed significant activity and the results are comparable with the standard drug, diclofenac. None of the compounds exhibited significant activity in anti-bacterial study. The work might result in the emergence of new series of compounds with potent anti-inflammatory activity.

Keywords: Imidazo [1, 2-a] pyridines, isoxazole hydrazides, Schiff bases, anti-bacterial activity, anti-inflammatory activity

 


[PDF]  Viewed: 165  Downloaded: 54
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter