DOI: 10.21276/ajptr
Fri, 24 May 2019

Synthesis, Characterization of Some Novel Schiff bases Derived from Imidazo [1, 2-a] pyridines for Anti-inflammatory and Antibacterial Activities

Mood Sikender1, Ameena Begum1, Rishika Unyala1, Chirra Hepsibha1, B.Madhava Reddy1, V.Harinadha Babu1*

1.Department of Medicinal Chemistry, G.Pulla Reddy College Of Pharmacy, Mehdipatnam, Hyderabad-500028


Imidazo [1, 2-a] pyridine based Schiff bases have been synthesized by condensing different 3-aryl-5-methyl isoxazole hydrazides with 2-aryl imidazo [1, 2-a] pyridine carbaldehydes by following hybridization approach. The structures of newly synthesized Schiff bases have been characterized by spectral data and elemental analysis. In In vivo anti-inflammatory screening, compounds 4b & 4f showed significant activity and the results are comparable with the standard drug, diclofenac. None of the compounds exhibited significant activity in anti-bacterial study. The work might result in the emergence of new series of compounds with potent anti-inflammatory activity.

Keywords: Imidazo [1, 2-a] pyridines, isoxazole hydrazides, Schiff bases, anti-bacterial activity, anti-inflammatory activity


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