DOI: 10.21276/ajptr
Fri, 19 Apr 2019

Formulation Development, Optimization and In-Vitro Evaluation of Ginger Root Extract (5%w/w 6-Gingerol) 300mg Timed Release Veggie Capsules.

Manoj Kumar Katual1*, S.L.Harikumar2

1. Rayat-Bahra Institute of Pharmacy, Education City, Hoshiarpur, Punjab, India.

2. University School of Pharmaceutical Sciences ,Rayat-Bahra University, Mohali, Punjab, India.


The major objective of any dosage form development is to ensure the delivery of specific and reproducible amounts of pharmacologically active compounds to the body in the maximum amount possible. Today's most frequently used dosage forms are orally administered solids formulated such as tablets, capsules or powders. Timed-release products intend to improve delivery efficacy and/or effectiveness; for instance, the frequency of dosing can be reduced and, in certain cases, the actual daily dose can be reduced, offering the manufacturer a financial benefit. There have been many techniques developed for producing the variety of timed-release products. Ginger is a natural drug, which is used for nausea and vomiting, to treat bleeding disorders and rheumatism. In conventional dose is thrice a day, 8-10 gm which is not at all convenient for the patient. Increase the patient compliance is also a great challenge which is continuously improving by the novel drug delivery system. The main objective of the present work is to design Ginger root extract powder (5%w/w of 6-gingerol) timed release dosage form of the drug with the help of a novel clear transparent veggie capsule shell of ‘0’ size made up of cellulose and natural substance. The objective in formulating a sustained release dosage form is to be able to provide a similar blood plasma level pattern for up to desired hrs (12hrs) after oral administration of the drug. The formulation, optimization, destructive quantification parameters and in-vitro studies of the drug have focused in this research article. The presented work sought a futuristic research for the benefit of the patients.

Keywords: Sustained Release, Timed drug delivery, Novel drug delivery, Veggie Capsules

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