Wed, 22 Nov 2017

Synthesis, Anxiolytic and Tranquilizing Activity of Some New 1, 4-Diazepine Derivatives.

Bothaina A. Mousa1, Maha M.A. Khalifa,2 Eman A. Fayed, 3* Makarem M. Said and Hebatalla I. Ahmed.4

1.Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt; 2.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University (Girls), 11754, Cairo, Egypt;

3.Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University (Girls), 11754, Cairo, Egypt; 4 Department of Pharmacology and Toxicology, Faculty of Pharmacy Al-Azhar University (Girls).


ABSTRACT

Synthesis of certain new fused 1,4-diazepine derivatives, namely, cyclopentathienodiazepinones and their benzothieno analogues IV to produce new compounds of possible CNS depressant activity. Eleven compounds IV 1, 5, 6, 7, 12, 13, 15, 19, 20, 21 & 26 were selected and submitted to pharmacological evaluation for anxiolytic and tranquilizing activity in the open field test.

Keywords: 1,4-Diazepine derivatives, Open-Field test, Anxiolytic and Tranquilizing Activity

 


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