Wed, 22 Nov 2017

Drug Repurposing: Risk- Benefits and Associated Incentives

M. P. Venkatesh 1*,  Kavya Sravanthi G1, T.M. Pramod Kumar1

1.Department of Pharmaceutics, Regulatory Affairs Group, JSS College of Pharmacy,

2.Jagadguru Sri Shivarathreeshwara University, S.S Nagar, Mysuru – 570015, Karnataka, India


ABSTRACT

Pharmaceutical R&D is failing with an era of triple obstacles – increased timelines for approval, high cost and even higher failure rates. The world around us is constantly putting pressure on creating completely new solutions for about 4000 diseases with known molecular basics and many other diseases without basic intellect. There comes a need to remove the wide gap in innovation showcasing a challenge for drug discovery. The shockingly tedious drug development process is forcing us to find more effective solutions and drug repurposing can be a starting point where the clear understanding of the de novo pathway for an existing drug essentially unlocks the full potential for repurposing a drug for other diseases. Drug repositioning (also known as drug repurposing, re-profiling, re-tasking or therapeutic switching) is the application of known  drugs and compounds to new indications (i.e., new diseases). This idea dates back with cases like Viagra, Thalidomide, and Aspirin etc. There are a number of approaches to drug repurposing, but these are ultimately an expedition into new area. Scientists have to justify examining a compound in a different disease state, so they often make a hypothesis based on possible associations between mechanisms. A significant advantage of drug repositioning over traditional drug development is that since the repositioned drug has already passed a significant number of toxicity and other tests, its safety is known and the risk of failure for reasons of adverse toxicology are reduced. The possibilities are endless, and animal models are elevating drug repurposing's potential.

Keywords: Drug Repurposing, New indications, de-novo pathway.


[PDF]  Viewed: 160  Downloaded: 38
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter