Wed, 22 Nov 2017

In-vitro Anticancer Activity and Essential oil Composition of Tridax procumbens (L.)

K. Poonkodi1*,  V. Jayapriya1, K. Sujitha1, R. Jeevitha1, PU. Megha1

1.PG Department Of Chemistry, NGM College, Pollachi, Tamilnadu, India-642001


ABSTRACT

The present study investigates the chemical composition of essential oil of leaves of Tridax procumbens (L.) and its invitro anticancer activity.  Traditionally, the plant is used for malaria, stomachache, high blood pressure, hemorrhage and to prevent hair fall as well. It possesses antifungal, antibacterial, antiseptic, insecticidal, parasiticidal and hepatoprotective properties. The hydrodistilled essential oil of T.procumbens contains total of 18 components by GC-MS analysis. Dibutyl phthalate (19.29%), Trans-(α)-caryophyllene (9.55%), Biformeme (3.95%), p-cymen-7-ol (2.52%), 1,8-cineole (2.44%). And the minor compounds are trans-α- Bergamotol (1.78%), 2-α-pinene (1.62%), α-Selinine (1.49%), Caryophyllene oxide (1.39%), α-humulene (0.95%),  The obtained essential oil was tested against Human breast cancer cell line (MCF-7) for its anticancer activity by MTT assay with different concentrations of essential oil (18.5-300 µg/ml). The result revealed that the essential oil showed concentration dependent activity against cell line. The IC50 value of MCF-7cell line was 96.6 µg/ml. This may be due to the presence of important terpenes present in the oil. There are only few reports are available for anticancer activity efficacy of this plant. Our findings confirm the anticancer potential of the T.procumbens.

Keywords: T. procumbens, Dibutyl phthalate, Trans-(α)-caryophyllene, Biformeme and MCF-7

 


[PDF]  Viewed: 180  Downloaded: 53
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter