Wed, 22 Nov 2017

Formulation and Evaluation of Gumghatti Nanoparticles Comprising of Cyclophosphamide For Enhanced Antitumor Activity

Surendiran NS1 *, Mohan S2

 1.Department of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Chudella, Jhujhunu-333 001, Rajasthan, India

2. Faculty of Pharmacy, Karpagam College of Pharmacy, Mayileripalayam, Coimbatore-641 032, Tamilnadu, India


ABSTRACT

In this current research work the nanoparticles containing Cyclophosphamide using natural Gumghatti as a polymer has been formulated for the enhanced anticancer activity. The nanoprecipitation method has been utilized for the preparation of Cyclophosphamide comprising natural Gumghatti as polymer. The prepared nanoparticles have shown the average particle size, polydispersity index and zeta potential of 143.4 nm, 0.16 and 28.5 mV respectively. Further the encapsulation efficiency, percentage drug loading and percentage yield for all the formulations were substantial, especially for the trial 6 the values observed were 93.56, 83.55 and 76.54 respectively. The invitro release of Cyclophosphamide Gumghatti nanoformulations and were determined by dissolution tester by USP apparatus II in 900ml phosphate buffer pH 6.8. The dissolution media were maintained at 37±0.5°C with a paddle rotation speed at 50 rpm. The amount of drug used was equivalent to 15 mg at specified time intervals (5, 10 15, 20, 25 30 60, 90 and 120 minutes.) The results shows that prepared nanoparticles having 98.53 % of drug release in 120 minutes, further it indicates more than 95 % of drug release in 2 hours. Invivo anticancer activity has been performed using Swiss albino mice, the results indicated that the enhanced anticancer activity of the prepared nanoformulations.

Keywords: Cyclophosphamide, Gumghatti, Nanoprecipitation, invitro drug release, anticancer activity.


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