Wed, 22 Nov 2017

Novel strategies for Neuro-Dysfunction management through Percutaneous Route: A Current Perspective.

Gurdeep Kaur1*, Manoj Kumar Katual1, Radhika Sharma1, Sandeep Kaur1

1.Rayat-Bahra Institute of Pharmacy, Education City, hoshiarpur, Punjab, India,146001

2.University School of Pharmaceutical Sciences, Rayat-Bahra University, Mohali, Punjab.


ABSTRACT

Neurodegenerative disorders are conditions in which cells of the brain and/or spinal cord degenerate.  The brain and spinal cord are composed of neurons with different functions such as controlling skilled movements, processing sensory information, storage of information and making decisions. Cells of the brain and spinal cord do not usually regenerate, so damage to the nervous system can be devastating. Normally, the neurodegenerative process begins long before any symptoms appear. Neurodegenerative diseases result from deterioration of neurons or their myelin sheaths which over time will lead to dysfunction and disabilities. Neuro-degenerative diseases markedly affect the lives of millions and lead to a growing public health challenge with increased costs for individuals and society. The prevention and treatment of these neurodegenerative disorders represent a critical goal of medical research today. Most of these disorders increase with age. Today, there are 25 million suffering from dementia and it is generally believed that the prevalence will be 130 million demented persons by 2050. As the human outer skin proved it to be the largest organ of sense of body, that can be potentially used for the delivery of multiple therapy for the successful management of neurobehavioral disorders. Various novel approaches can be introduced for which further study is essential .The focus on this route has not been in limelight till yet. Transdermal drug delivery is helpful for topical and local action of the drug. . For the patients who have difficulties swallowing solids or liquids, a transdermal drug delivery may offer great advantages over conventional delivery methods. Drug delivery directly to the brain interstitium has recently been markedly enhanced through the rational design of polymer-based drug delivery system. After the oral administration of drugs, the huge variations were associated in plasma levels with regular gastintestinal symptoms including nausea, vomiting, diarrhea, constipation, anorexia, abdominal pain and abdominal distention. This drug administration route could therefore allow optimal therapeutic dose, potentially further improving the effectiveness of treatment. The transdermal delivery bypasses the first past metabolism and lesser side effects. This route may be explored for the delivery of nano-sized pharmaceuticals to the CNS as an alternate route.

Keywords: Parkinson’s disease, Neurological behaviors, BBB, Nanotechnology, Skin.


[PDF]  Viewed: 155  Downloaded: 37
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter