Wed, 22 Nov 2017

Nanocochleates - A Novel Tool For Oral Drug Delivery System.

Monika Dnyandev Gade1*, Kishor Sahebrao Salunkhe1, Mallappa Saibanna Harwalkar2

1. University of Savitribai Phule Pune, Pune.  Amrutvahini College of pharmacy, Sangamner- 422605, Maharashtra, India

2.Aurobindo Pharma limited. Hyderabad, Telangana.


ABSTRACT

Nanocochleates are unique novel drug delivery system in which, the desire drug molecule gets encapsulated into the multilayer of lipid crystal matrix. The nanocochleates structure provides protection to encochleated molecules from the degradation. It composed of negatively charged lipid generally phosphatidylserine and calcium. The nanocochleate structure has potential to carry the molecules which are hydrophobic, positively charged, negatively charged and that possess poor oral bioavailability. Nanocochleates is having more advantages than that of other dosage forms and system and hence it represents a new technology for oral and systemic delivery of drugs.

Keywords: Nanocochleates, Encochleated, Oral bioavailability, Systemic delivery.


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