Wed, 22 Nov 2017

Review on Topical Liposome: Drug Delivery Through Skin

Gitanjali Shivaji Bhatjire1*, Santosh Dattu Navale 1, Kishor Sahebrao Salunkhe1

1.Department of Pharmaceutics, Amrutvahini College of Pharmacy, Sangamner 422605, India


ABSTRACT

Liposome proved themselves as a promising novel delivery vehicle of drugs to the skin, is a topic of considerable current interest. Liposomes are acceptable and superior carriers having ability to encapsulate both hydrophilic and lipophilic drugs and protect them from degradation. Liposomes are result of self-assembly of phospholipid in an aqueous media resulting in closed bilayer structures. Liposomes are one of unique drug delivery system which can be used in controlling and targeting drug delivery system. Liposomes are generally classified based upon structure, method of preparation, composition and application, conventional liposome, and specialty liposome. Different marketed formulations are available in market for liposomes. The liposomes have many applications which increase its importance over other formulations. The entrapped compound’s solubility and partitioning characteristics will determine its location in the liposomal bilayer .It also has affinity to keratin of horny layer of skin and can penetrate deeper into skin hence give better absorption. But they may also have the property into the skin, carrying actives to the target site, where these molecules will be released. Reformulation of drugs in liposomes has provided an opportunity to enhance the therapeutic indices of various agents. This review discusses the potential advantages in topical drug delivery, basic structure characteristics and mechanism of action of liposomes and evaluation parameter for liposome formulation.

Keywords: Liposome, penetration, skin, enhanced efficiency.


[PDF]  Viewed: 171  Downloaded: 48
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter