Thu, 14 Dec 2017

A Review on Analytical Methods for Estimation of Modafinil

K. K. Patel1*, Dr. S. S. Pandya2, V. S. Patel3

1.Ph.D. Student, HNGU, Patan, Gujarat, India.

2.Shree Swaminarayan Sanskar Pharmacy College, Ta and Dist- Gandhinagar, At- Zundal, Gujarat-382421, India.

3.Troikaa Pharmaceutical Ltd. Ahmedabad, Gujarat, India.


ABSTRACT

Modafinil is a wakefulness - promoting agent  (or eugeroic) used for treatment of disorders such as narcolepsy, shift work sleep disorder, and excessive  daytime sleepiness associated with obstructive sleep apnea.  It is sold under the brand names Alertec, Modavigil, and Provigil. Various analytical methods used for the estimation of Modafinil have been reviewed in this paper. These include Ultraviolet Spectrophotometry, RP-HPLC, Stability indicating RP-HPLC, HPTLC, Capillary zone electrophoresis, simultaneous determination by HPLC, LC-MS/MS, Liquid –liquid extraction,  HPLC , bidimensional HPLC, GC-MS and Solid-phase extraction followed by HPLC  in rat serum and urine  to determine the amount of Modafinil in bulk drug, pharmaceutical dosage form and biological fluids. These analytical methods can be used for qualitative and quantitative estimation of Modafinil in bulk, formulation and biological fluids.

Keywords: Modafinil, bulk drug, dosage form, biological fluids, analytical methods, estimation.


[PDF]  Viewed: 116  Downloaded: 84
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter