Thu, 14 Dec 2017

Evaluation of Cytotoxic Properties of All-Trans-Retinol on Breast Cancer and Prostate Cancer Cells

Animisha Mokkapati1, Nitya Rudraraju2, Radhakrishna Nagumantri1, Chinnababu Pydi1, Satyanarayana Rentala1, *

1.Department of Biotechnology, Institute of Technology, GITAM University, Visakhapatnam 530045

2.Department of Biomedical Engineering, Boston University, Boston USA


ABSTRACT

Vitamin A and its derivatives (known as retinoids) play a crucial role in vision, inhibition of cell proliferation, cell division and differentiation and Fetal development. The active form of vitamin A is retinol, also known as vitamin A1 is found in animal products as preformed vitamin A. All-trans-retinol (vitamin A) has been studied as antioxidant in in vitro but limited data is available on cytotoxic effects of retinol on cancer cell lines. In this paper, the cytotoxic effects of retinol on breast cancer cells (MDA-MB-231) and prostate cancer cells (PC-3) were studied. Our experiments showed that maximum cytotoxicity was achieved at 48 hours and at 100µM concentration of all-trans-retinol on both the cell lines. The results have significant implications for understanding anti-cancer effects of all-trans-retinol on breast and prostate cancer cell lines.

Keywords: Vitamin A (all-trans-retinol), Cytotoxicity assays, MTT assay, Prostate cancer cells and Breast cancer cells.


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