Thu, 14 Dec 2017

Formulation and Evaluation of Controlled Release Polymeric Microparticles of Eprosartan Mesylate

P. Palanisamy*, B.Jaykar, R.Margret Chandira, S. Thimya, K. Thirunavukarasu, V.N. Sukanya, M.K. Thahir

Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, Vinayaka Missions University, Salem (D.T), Tamil Nadu(State), India


ABSTRACT

In the present research study focuses on formulate and evaluate Polymeric Microparticles of Eprosartan Mesylate aiming to increase the therapeutic efficacy, reduce the frequency of administration and to improve the patient compliance. Controlled release polymeric microparticles of Eprosartan Mesylate, were formulate by using different drug polymer ratios HPMC Phthalate and Eudragit S 100. The various formulations of controlled release Polymeric Microparticles of Eprosartan Mesylate were formulated by using various concentrations of different polymers HPMC Phthalate and Eudragit S 100 by fusion method. The Polymeric Microparticles were evaluated for pre compression and post compression parameters (Angle of repose, Tapped density & Percentage compressibility index) and In-vitro dissolution. The results indicated that the, physical parameters of microparticles were within the Pharmacopeial specifications. Among the different formulation, F4 showed controlled release of drug for 24 hours with 80.27% release. The kinetic drug release, the data was treated according to different model. The drug release data of F1-F5 fitted to Higuchi plots were best fit into Higuchi equation and diffusion mechanism. The result shows that, drug release rate for the F4 formulation follow the zero order mechanism. The selected formulation (F4) was subjected to stability studies for three months at 25°C/60% RH, 30°C/65% RH and 40°C/75% RH and showed stability with respect to release pattern and all physical parameters. Thus, drug in Polymeric Microparticles with Eudragit S 100 were found to be effective in retarding the release of Eprosartan Mesylate.

Keywords:  Eprosartan Mesylate, controlled release polymeric microparticles, HPMC phthalate,  Eudragit S 100.


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