Thu, 14 Dec 2017

Synthesis and Anticonvulsant Screening of 2 Mercaptobenzimidazole Derivatives

Kiran M  Kulkarni *, Sagar A. Jadhav, Vipul M. Patil, Shital. S.Patil

1.Department of Pharmaceutical Chemistry, Ashokrao Mane College of Pharmacy , Peth Vadgaon, Kolhapur, Maharashtra, India


ABSTRACT

The novel series of 2-mercaptobenzimodazole derivative were synthesized by using secondary amine i.e. diethyl amine and aromatic aldehyde. In Mannish reaction instead of formaldehyde other aromatic aldehyde was used. This was main aim of present study. Same derivatives were synthesized by using Microwave technique & reaction time, practice yield were compared. The purity of synthesized compounds was checked by Melting point and TLC and their structure was established by various analytical techniques such as IR,1HNMR, Mass spectral studies. These Compounds were screened for their  Anticonvulsant activity.  Anticonvulsant activity was evaluated by PTZ induced model.

Keyword- Mannich reaction, 2-Mercapto Benzimidazole, Aromatic aldehyde.


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