Thu, 14 Dec 2017

Formulation and Evaluation of Diclofenac Sodium Effervescent Tablets

Pulla Sravanthi 1* , Kodumagondla Divya1

1 .Department of Pharmaceutics , S.R.R.College of Pharmaceutical Sciences,Valbhapur, Elkathurthy, Warangal( U) -


ABSTRACT

The main objective of present work is to formulate and evaluate Diclofenac sodium Effervescent tablets. Diclofenac sodium is an established analgesic developed for rapid absorption, which may be beneficial in treating acute migraine. Diclofenac sodium Effervescent tablets was prepared using excipients like sodium bicarbonate, citric acid, mannitol, sodium benzoate, talc, vanillin and varying concentrations of Sodium starch glycolate and croscarmellose using direct compression technique. The powder blend of all formulations were evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. All the prepared formulations were tested for physical parameters like weight variation, thickness, hardness, friability ,assay ,effervescence time, wetting time and PH and found to be within the pharmacopoeia limits .Optimized formulation was selected based on the criteria the max amount of drug release within 9 min. Among six formulations F3 was found to be the best formulation as more than 90% of drug is released within 9 min compared to other formulations. The drug release profiles of optimized Diclofenac sodium effervescent tablets was compared with that of dispersible marketed product and it was observed that the drug release from effervescent tablets was much faster than that of marketed dispersible tablets. 

Keywords: Effervescent tablets, Diclofenac sodium, Direct compression method, In vitro dissolution studies


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