DOI: 10.21276/ajptr
Thu, 23 May 2019

Synthesis, Characterization and Biological Activities of (3-Nitrophenyl)(5-Substituted Phenyl- 1,3,4-Thiadiazol-2-Yl) Methanediamine

Konda Ravi Kumar1*, B. L. Rani2, K.N.S.Karthik1

1. Hindu college of pharmacy, Amaravathi road, Guntur, A.P.India.

2.Chalapathi institute of Engineering and Technology, Lam, Guntur, India


Synthesis of phenyl (5-substituted phenyl-1,3,4-thiadiazol-2-yl) methanediamine (TDZ-A to TDZ-C), reaction between aryl aldehydes and Thiosemicarbazide yielded thiosemicarbazone. Thiosemicarbazone in the presence of citric acid and sodium acetate gives 2-amino-5-aryl -1,3,4-thiadiazole, which is treated with aniline in the presence of formaldehyde to obtained targeted compounds phenyl(5-substituted phenyl-1,3,4-thiadiazol-2-yl)methanediamine. The synthesized Thiadiazoles have been characterized on the basis of analytical spectral data. The resulted compounds were screened for their antibacterial, antifungal and antioxidant activities.

Keywords: Aromatic aldehydes, Thiosemicarbazide, Formaldehyde, Antioxidant activity, Antibacterial activity, Antifungal activity.

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