DOI: 10.21276/ajptr
Mon, 27 May 2019

Synthesis of Novel Clubbed Triazolyl Indeno[1,2-C]Isoquinolines As Potent Anticancer Agents

John Thomas*1, Mahendra ShiradkarJisha James 3Golwala Dharmesh1

1. Research Development and Innovation centre (RDIC), C.U. Shah University, Wadhwancity 363030

2.Amneal Pharmaceuticals, Aurangabad 431009

3. KVM College of Pharmacy, Kokkothamangalam P.O.Cherthala 688529


A variety of novel clubbed triazolyl indeno[1,2-c]isoquinolines 14-21 derivatives were synthesized in good yields and characterized by IR, 1H NMR, mass spectral and elemental analyses. All the newly synthesized compounds were evaluated for their in-vitro anticancer activity and topoisomerase I inhibition. Several compounds showed interesting cytotoxic activities when compared with the Doxorubicin as a reference drug.

Keywords: Clubbed triazoles, topoisomerase

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