DOI: 10.21276/ajptr
Mon, 27 May 2019

Synthesis and evaluation of some polysaccharide-corticosteroide conjugates as colon specific prodrug.

Sandhya Jain1*, Lopamudra Banerjee1

1.Department Of Pharmaceutical Sciences Dr. Hari Singh Gour Centrel University Sagar (M.P.)470003


To synthesize Prednisolone-succinate-dextran.βcyclodextrin and chitosan conjugate and to evaluate the potentiality of conjugates for the treatment of inflammatory bowel diseases. Prednisolone was attached to dextran, chitosan and βcyclodextrin using succinate anhydride in an anhydrous environment catalyzed by 4-dimethylaminopyridine. The chemical structure of conjugates was identified by IR and NMR, The Prednoisolone conjugates was obtained in two steps and the in vivo drug release behavior of conjugates was investigated after oral administration of  prodrugs suspension. The Prednisolone conjugates was stable in rat stomach and small intestine and negligibly absorbed from these tracts and easily hydrolyzed by an esterase. The results of this study indicate that Prednisolone conjugates may be useful in selectively delivering corticosteroids to the colon.

Keywords: Prednisolone succinate(pds),dextran(Dxt).βcyclodextrin(β-CyD)and chitosan(Cht), conjugate. 4-dimethylaminopyridine(DAMP), N-hydroxy succinimide (NHS)

[PDF]   Viewed: 523   Downloaded: 66
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter