Sat, 18 Nov 2017

Recent Synthesis and Biological Applications of Novel Benzotriazoles: A Review

Aman Bhalla1*, Shamsher S. Bari1, Anu Kumari1

1.Department of Chemistry, Panjab University and Centre of Advanced Studies in Chemistry, Chandigarh 160014, U. T., India


ABSTRACT

The area of pharmaceuticals and synthetic organic chemistry continued to remain dependent on the heterocyclic compounds due to their wide array of properties both biological and synthetic. However, their extensive clinical use as medicinal drugs and their synthetic applications has been prompting the chemists to develop new structural triazole derivatives. Benzotriazole is benzene fused azole derivative exhibiting tremendous application in medicinal and synthetic chemistry. Benzotriazole bearing compounds possess various activities such as anticancer, antifungal, antibacterial, antitubercular, antiviral, antioxidative, antiparasitic, antioxidative. Also, the versatility and usefulness of benzotriazole methodology in synthesis protocol has grown from an obscure level to extreme popularity, since benzotriazole moiety can easily be introduced into a molecule by variety of reactions, thus allowing numerous transformations, and finally its stability and ease of removal at the of the reaction sequence.  In this review, we briefly describe the development of new benzotriazole compounds having wide range of applications during the period of 2011 to 2016.

Keywords: Benzotriazole, antibacterial, antimicrobial, peptide, hydrazides.  


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