DOI: 10.21276/ajptr
Tue, 19 Feb 2019

Green Synthesis of 2-Substitutedimino-4-Amino-6-Ethylformamidino-1,3,5-Thiadiazines

D.T.Tayade1* S.P. Ingole1, A.S. Shendge1

1. Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati 444606.


“Non-conventional” synthetic method has shown broad applications as a very efficient way to accelerate the course of many organic reactions, producing high yields, higher selectivity and lower quantities of side products consequently easier work-up and purification of the products.  One-pot two-component condensation of 1-formamidino-5-ethylformamidonothicarbamide (llla) with various isocyano-dichlorides (Xla-g) were carried out in presence of lemon juice as a biocatalyst respectively to synthesize a novel series of 2-substitutedimino-4-amino-6-ethylformamidino-1,3,5-thiadiazines (Xlla-g) which are either to unknown. The structures were confirmed by conventional chemical characterization, elemental analysis and spectral studies.  

Keywords: Lemon Juice, various isocyanodichlorides, 1-formamidino-5-ethylformamidonothicarbamide.


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