Sat, 18 Nov 2017

Combined Tulsi Extract and Cinnamon oil Reduce Hypercholesterolemia in Dyslipidemic Rats.

Akshay Javalgikar1*,Nitin Mahurkar,2 Aarti Malpani,3 Keerthi karri4

1.Department of Pharmacology, D.S.T.S. College of Pharmacy, Solapur-413004, Maharashtra

2. Department of Pharmacology, H.K.E.S’s MTRIPS, Kalaburagi- 585 105, Karnataka.


ABSTRACT

The studies were intended to investigate the possible antihyperlipidemic effect of tulsi and cinnamon oil in high cholesterol diet induced hyperlipidemic rats. Tulsi and cinnamon oil were evaluated for antihyperlipidemic activity using high cholesterol diet induced hyperlipidemia model in male Wistar albino rats(200-250g). A comparison was also made between the action of tulsi(0.5 mg/kg b.w) and cinnamon oil extracts(1.8mg/200g b.w) and antihyperlipidemic drug atorvastatin (0.18mg/200g). Parameters assessed were body weight, total cholesterol, triglyceride, HDL-C, LDL-C.  The results of the study are represented by mean ± SEM. Statistical significance of data was assessed by one way analysis of variance (ANOVA) followed by a comparison between different groups using “Tukey - Kramer” test. Oral administration of 0.5 mg/kg of tulsi oil with dist. water and Cinnamon oil of 1.8 mg/200g suspended in tween80 solution exhibited significant reduction (p ˂ 0.01) in serum biochemical parameters total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL)  and increase in high density lipoprotein (HDL) levels in hyperlipidemic rats of HC diet model  compared to hyperlipidemic positive control. The results demonstrated that tulsi and cinnamon oil extracts possessed significant antihyperlipidemic activity.

Keywords: Tulsi oil, Cinnamon oil, Atorvastatin, High cholesterol diet, Hyperlipidemia.


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