DOI: 10.21276/ajptr
Mon, 20 May 2019

Synthesis, Characterization and Antimicrobial Activities of Some Novel 2-Azetidinones Derived from Cyanoethyl Tertiaryamino Benzaldehydes

Pradeep K. Soni1*, Ravi Bansal1, A.K. Halve1, J.S. Parihar2

1. School of Studies in Chemistry, Jiwaji University, Gwalior (M.P.), India

2. Govt. Maharaja Auto. P.G. College Chhatarpur (M.P.), India


Present report is the successful synthesis, spectral characterization and in-vitro antimicrobial evaluation of a series of azomethine and novel 2-azetidinone derivatives. Two cyanoethylated tertiaryaminobezaldehydes A and B were prepared by cyanoethylation of the corresponding aromatic primary amines followed by formylation in presence of POCl3 and DMF. These cyanoethylated tertiaryaminobenzaldehydes on condensation with different aromatic primary amines afforded azomethines SB1-SB14, which on cyclization with chloroacetylchloride and triethylamines in 1,4-dioxan gave new 2-azetidinone BL1-BL14. All compounds were prepared by reported methodology and characterized by elemental analysis, FT-IR and 1HNMR data. Further screened in-vitro for antimicrobial activity against S. aureus, B. subtilis, P. vulgaris, E. coli, A. niger and A. fumigatus. Most of the compounds showed significant activity against tested pathogens. The work shows the emergence of a new series of compounds in the field of antimicrobials.

Keywords: 2-Azetidinones, azomethines, antimicrobial activity, cyanoethylation, formylation, tertiaryaminobenzaldehydes.

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