DOI: 10.21276/ajptr
Mon, 20 May 2019

Effectiveness of different extracts of cocoa powder on plasma glucose and lipid profile in alloxan-induced diabetes mellitus rats.

Olooto E. Wasiu1*, Alabi O Akinyinka2, Aderinola, A. Aderonke2, Muritala A Abdullahi2

1.Department of Chemical Pathology and Immunology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ago-Iwoye

2.Department of Pharmacology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ago-Iwoye


The use of different solvents to extract plant materials is to obtain component of utmost activity for the management of various disease conditions. Cocoa powder was subjected to different menstruum (aqueous, ethanol, n-hexane and chloroform) to remove inert materials and obtain pure active components whose effect was determined. Diabetes was induced in forty female Albino rats divided randomly into five groups, each consisting of eight rats, using 120mg/kg body weight alloxan. Different extracts of the powder were administered orally for twenty one days at a dose of 200mg/kg each except in the diabetic untreated group. Fasting blood sample was collected from the tail vein daily to determine the blood glucose concentration. On 22nd day, fasting blood samples were collected from all the rats for lipid profile estimation. Results showed a significant decrease (P<0.05) in the blood glucose level in ethanol extract-treated diabetic group compared with the others and a decrease in plasma TC, TG, and LDL-C in the extract-treated groups when compared with the diabetic untreated group. The reduction in lipid profile was significant (p<0.05) in ethanol extract when compared to other extracts. Conclusively ethanol extract of cocoa powder exhibited significant antihyperglycemia, hypolipodemia, and reduction in LDL-C.

Key words: Cocoa powder, diabetes mellitus, blood glucose, lipid profile, atherogenic index.

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