Sat, 18 Nov 2017

Evaluation of Pharmacological Activities of Stay-On Power Capsules In Rats

Saiprasanna Behera1*, Mrinmoy Gautam1, Prasanta Kumar Choudhury2, Jayesh Mehta3, Mangesh Chandrakant Khadakban3

1. Department of Research and Development, Mudra Clincare, Bhubaneshwar, Odisha. India-751014

2. Royal College of Pharmacy and Health Sciences, Berhampur, Odisha- 760002

3. Department of Formulation & Development, Shree Maruti Herbal, Mumbai, Maharashtra. India- 400003


ABSTRACT

The main objective of this study was to perform pharmacological evaluation of Stay-On Power Capsules in Rats namely the aphrodisiac activity. The present investigation deals with Pharmacological Studies (Mating behaviour study, mating performance test, Hormonal analysis, Reproductive organ and spermal analysis) of Stay-On Power Capsules in Rats administered orally by gavage to rats in accordance with the schedule Y of drugs and Cosmetic Act (2005). The acute toxicity study of Stay-On Power Capsules was done by up and down method. After the completion of acute toxicity studies, three different doses were selected for aphrodisiac activity such as 150, 300, and 600 mg/kg. Volume of oral administration was 1 ml/100 g of animals. Animals were randomly divided into five groups with six animals per group. Group I represented the control animals treated with normal water only; Groups II, III, and IV were treated with oral suspension of Stay-On Power Capsules at 18:00 h, at doses of 150, 300, and 600 mg/kg, respectively; and Group V served as a positive control treated with Sildenafil citrate of 5 mg/kg body weight. All the treatments were continued for 3 weeks only. Daily administration of Stay-On Power Capsules for 3 weeks to male rats resulted in a dose dependent increase in the mating performance as compared to the control group. The Stay-On Power Capsules at the dose of 150, 300, and 600 mg/kg showed 52.66%, 63.83%, 71% mating performance, respectively, against 38.33% of the control group, whereas the standard showed 79.66% mating performance. The Stay-On Power Capsules had significantly increasing (**P < 0.01) effect on testosterone, LH, and FSH concentration in the serum in comparison to the control group. Oral administration of Stay-On Power Capsules for 3 weeks has been found to be relatively safe and effective in Mating behaviour study, mating performance test, Hormonal analysis, Reproductive organ and spermal analysis in rats.

Keywords: Mating behaviour study, mating performance test, Hormonal analysis, Reproductive organ and spermal analysis


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