Wed, 18 Oct 2017

Isolation, Recovery and Analysis of Active Drug From Formulation

Kumar Pratyush1* , Alpana Asnani 1,Priya Dule1, Prakash Helonde2

1. Priyadarshini J.L. College of Pharmacy, Electronic Building, Electronic zone, Hingna Road, Nagpur – 440016, Maharashtra.


ABSTRACT

Drugs are used in pharmaceutical formulation to serve the mankind and help them to maintain their Quality of Life. As per literature survey we found that there are a fair number of paper that explains the formulation of dosage form by certain drugs, but none of them with explaining the aspect of isolation and retrieving of the active drug from the dosage form. In the current study Paracetamol is taken as the active drug which is used to formulate the best batch of tablet and then the drug is retrieved back from the best found formulation by the help of specific solvent. This solvent was determined by trial of several combinations and the best selected results are mentioned. 96.24 % of the active agents were isolated by the help of selected solvent. The drug compatibility study was carried out by Fourier Transform Infrared spectroscopy (FT-IR) and the structure determination of the isolated active agent was carried out by the Nuclear Magnetic Resonance (NMR) results. The assay of isolated active agent was carried out by UV spectroscopy. All these analytical data helped to elucidate the structure of isolated active agent and was found similar to that of Paracetamol.

Keywords: Quality of Life, active agent, paracetamol, UV, FT-IR, NMR.


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