Tue, 19 Dec 2017

Synthesis, Characterization of Some Novel Pyrazoline incorporated Imidazo[1,2-a]pyridines for anti-inflammatory and anti-bacterial activities

Bollam Nanda Kishore, Rishika Unyala, Ameena Begum, Chirra Hepsibha, B.Madhava Reddy, V.Harinadha Babu*

1.Department of Medicinal Chemistry, G.Pulla Reddy college of pharmacy, Osmania university, Mehdipatnam, Hyderabad-500028


ABSTRACT

Different phenacyl bromides were reacted with 2-amino pyridine to give 2-aryl imidazo[1,2-a] pyridines, which on subsequent reaction with Vilsmeier-Haack reagent gave 2-aryl imidazo[1,2-a] pyridine carbaldehydes (4a-4b). Claisen-Schmidt condensation of 4a and 4b with different substituted acetophenones afforded chalcones (5a-5f). The reaction of chalcones with phenyl hydrazine gave six new derivatives of pyrazolyl imidazo[1,2-a]pyridines (6a-6f ) in good yields. The synthesized compounds were characterised on the basis of physical and spectral data. The compounds were evaluated for anti-inflammatory and anti-bacterial activities. The compounds 6a, 6b, and 6c exhibited potent anti-inflammatory activity and results are comparable with standard drug, ibuprofen. None of the compounds showed any significant antimicrobial activity even at a concentration of 1000 µg/ml against Gram +ve and Gram –ve organisms.

Keywords: Imidazo[1,2-a] pyridine, Pyrazoline, Claisen-Schmidt condensation, Chalcone, Anti-inflammatory activity and Anti-bacterial activity.


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