Fri, 18 Aug 2017

Formulation and In-vitro Evaluation Of Glipizide Nanosponges

Swarupa Arvapally*, M. Harini, G.Harshitha, A.Arun kumar

1.Joginpally B.R Pharmacy college, Moinabad,Hydeabad.


ABSTRACT

In this study Β-Cyclodextrin facilitated Nanosponges were prepared by the solvent evaporation technique and subsequently formulated in a tablet form for immediate release of Glipizide. The Nanosponges formulations were prepared by solvent evaporation method employing Β-Cyclodextrin as a polymer. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. The surface morphology, particle size, production yield, and drug entrapment efficiency of Nanosponges were examined. Shape and surface morphology of the Nanosponges were examined using scanningelectron microscopy. Particle size of prepared Nanosponges was observed in the range of 428.7  to  633.5nm. Scanning electron microscopy revealed the porous, spherical nature of the Nanosponges.SEM photographs revealed the spherical nature of the Nanosponges in all variations; however, at higher ratios, drug crystals were observed on the nanosponge surface. Increase in the drug/polymer ratio (1:1 to 1:3) increased their yield (10.23 ± to 35.69), which is in increasing order due to the increase in the concentration of polymer but after certain concentration it was observed that as the ratio of drug to polymer was increased, the particle size decreased, the drug content of different formulations was found in the range 94.4to 98.6%,the entrapment efficiency of different formulations were found in the range of 82.11 to 94.40%, the drug  release of the Optimized formulation was found to be 97.71%.

Keywords: Glipizide, Β-Cyclodextrin, Dichloromethane, Nanosponges Delivery System (NDS). Scanning Electron Microscopy(SEM), UV Spectroscopy.


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