Wed, 18 Oct 2017

Formulation Optimization and Evaluations of Floating Tablet of Risperidone

Shaikh Siraj Nawaj1*, Aamir Sohel1,   G. J. Khan1, Mujahid Khan1

1.Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India


ABSTRACT

The objective of this research work was to formulate and evaluate the floating drug delivery system containing Risperidone drug, to improve oral bioavailability by increasing gastric residence time. Gastroretentive drug delivery system was developed by using Gum karaya & HPMC K 200M polymers. Formulations were prepared by using direct compression method. Optimization study was performed by using 32  full factorial design. The formulated floating tablets batches were evaluated for physicochemical parameters like hardness, thickness, weight variation, friability, drug content, floating lag time and swelling index. All prepared batches shown good in-vitro buoyancy studies and acceptable result of  for various parameters. Comparing the all the formulations, formulation R6 was considered as optimized formulation which exhibited 99.41% of drug release in 12 hours, floating lag time of 2.14 ± 2.0 minutes total floating time of over 12 hours.

Keyword: Floating, hardness, floating lag time, drug release.


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