Tue, 19 Dec 2017

Evaluation of Wound Healing Activity of Swietenia macrophylla (Meliaceae) Seed Extract in Albino Rats

Kiran Chanabasappa Nilugal*1 Santosh Fattepur 1, Mohd. Fadli Asmani1, Ibrahim Abdullah1, Santalaxme Vijendren,2 Ugandar R E3

1.School of Pharmacy, Management And Science University Shah Alam Selangor, Malaysia

2.School of Biomedicine Asia Metropolitan University, G-8, Jalan Kemacahaya, Taman Kemacahaya, Batu 9, Cheras- 43200, Selangor, Malaysia

3.Asia Pacific Higher Learning Sdn.Bhd. Petaling Jaya. Selangor Darul Ehsan. Malaysia.


ABSTRACT

The present study was aimed to evaluate the wound healing activity of extract of seeds of Swietenia macrophylla. It is well-known plant in Asian traditional medicines. On the basis of traditional use and literature references, this plant was selected for wound healing potential. The ethanolic extract of seeds of Swietenia macrophylla was examined for wound healing activity in the form of ointment in the excision wound model using Albino rats. The extract ointments showed efficient response in the excision wound model as comparable to the group treated with standard drug Betadine ointment and control group in terms of wound contracting ability, wound closure time and epitheliallization period. Histological analysis was also consistent with the proposal that Swietenia macrophylla seed extract exhibits significant wound healing. Swietenia macrophyllan was found to possess significant wound healing property. This was evident by decrease in wound closure (P<0.005) and epitheliallization period.

Keywords: Swietenia macrophylla, Wound healing, Betadine, ethanolic extract


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