Wed, 18 Oct 2017

Mixed hydrotropic technique as a tool to Enhance the solubility of Poorly Water Soluble Drug: Olmesartan

Himani Tewari1*, Arun Kumar Singh1, D. K. Sharma1

1. Devsthali Vidyapeeth, College of Pharmacy, Lalpur, Rudrapur- 263148, Uttarakhand, India


ABSTRACT

Current study was undertaken to improve solubility and bioavailability of poorly water soluble drug, Olmesartan. A mixed hydrotropic method was used to prepare the hydrotropes of Olmesartan. On the basis of screening Sodium Benzoate, Potassium Acetate and Tri Sodium Citrate hydrotropes were selected to prepare various hydrotropic solid dispersions of Olmesartan using selected hydrotropic agent in different ratio with the drug. The prepared solid dispersions were evaluated for solubility analysis, Drug Content Estimation, Fourier Transformed Infrared Spectroscopy, Differential Scanning Calorimetry, and In-vitro Dissolution Study of hydrotropes. From the study the results revealed that solubility was increased by using certain ratio (1:1:1:0.5) of drug with hydrotropic agents alone as well as in the combination. In the present study an attempt was made to prepare hydrotropes of a poorly water soluble drug Olmesartan to enhance the solubility and bioavailability of drug. The screening of different hydrotropic agents was performed to evaluate the best suited agent for drug hydrotrophs. On the basis of solubility analysis, the Sodium Benzoate, Potassium Acetate and Tri Sodium Citrate agents   have the ability to enhance the solubility of the drug more than 3 times of its original solubility. The method is economical and simple, to enhance the solubility of Olmesartan.

Keywords: Hydrotropy Method, Co solvent, Olmesartan, Physicochemical property, Sodium Benzoate, Potassium Acetate, Tri Sodium Citrate.


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