DOI: 10.21276/ajptr
Sun, 21 Jul 2019

Mixed hydrotropic technique as a tool to Enhance the solubility of Poorly Water Soluble Drug: Olmesartan

Himani Tewari1*, Arun Kumar Singh1, D. K. Sharma1

1. Devsthali Vidyapeeth, College of Pharmacy, Lalpur, Rudrapur- 263148, Uttarakhand, India


Current study was undertaken to improve solubility and bioavailability of poorly water soluble drug, Olmesartan. A mixed hydrotropic method was used to prepare the hydrotropes of Olmesartan. On the basis of screening Sodium Benzoate, Potassium Acetate and Tri Sodium Citrate hydrotropes were selected to prepare various hydrotropic solid dispersions of Olmesartan using selected hydrotropic agent in different ratio with the drug. The prepared solid dispersions were evaluated for solubility analysis, Drug Content Estimation, Fourier Transformed Infrared Spectroscopy, Differential Scanning Calorimetry, and In-vitro Dissolution Study of hydrotropes. From the study the results revealed that solubility was increased by using certain ratio (1:1:1:0.5) of drug with hydrotropic agents alone as well as in the combination. In the present study an attempt was made to prepare hydrotropes of a poorly water soluble drug Olmesartan to enhance the solubility and bioavailability of drug. The screening of different hydrotropic agents was performed to evaluate the best suited agent for drug hydrotrophs. On the basis of solubility analysis, the Sodium Benzoate, Potassium Acetate and Tri Sodium Citrate agents   have the ability to enhance the solubility of the drug more than 3 times of its original solubility. The method is economical and simple, to enhance the solubility of Olmesartan.

Keywords: Hydrotropy Method, Co solvent, Olmesartan, Physicochemical property, Sodium Benzoate, Potassium Acetate, Tri Sodium Citrate.

[PDF]   Viewed: 659   Downloaded: 90
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter