Wed, 18 Oct 2017

Design and Development of Immediate Release Tablets Amlodipine Besylate by Employing Modified Superdisintegrants

Ramana BV*, Murthy TEG K

1. Research Scholar, Rayalaseema University, Kurnool, Andhra Pradesh, India


ABSTRACT

The aim and objective of the present work is to design and develop fast disintegrating tablets of Amlodipine Besylate to improve the patient compliance and  desired bioavailability by selected delivery system by following immediate release mechanism. The drawbacks of the tablets can be overcome using methods involved in modified dissolving tablets, oral  dissolving  tablets (MDT) or orally disinter grating tablets (ODT) ; which started as an alternative oral dosage forms. To achieve successful delivery of drug , it  needs to be protected from degradation,  drug release to be improved and increase absorption. For this objective and to have the rapid  uptake of drug in solution form by rapid disintegrating formulation to be expected to have better  Therapeutic effect of both drugs in the gastrointestinal tract. The research objective   of the present work understands the novel advancements that are made in oral fast disintegration preparations incorporated anti hypertensive drug like Amlodipine Besylate using combination of super disintegrants.

Keywords: Amlodipine Besylate, Disintegration, Anti - Hypertensive, Bioavailability.

 


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