Wed, 18 Oct 2017

Formulation and In Vitro Evaluation of Garstroretentive Floating Tablets of Clarithromycin

Swathi P1, Heera B1, Srinivas Rao Y2, Bhavani B2*

1.AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam

2 .Vignan Institute of Pharmaceutical Technology, Visakhapatnam


ABSTRACT

Clarithromycin drug in the form tablet was formulated with different polymers. The object of the present work is preparing floating tablets in controlled fashion. The gas generating agent, sodium bicarbonate was added in different concentrations with varying amount of retardation polymers. Different grades of HPMC polymers HPMC K4M, K15M & K100M were used as retarding polymers. The formulation blend was evaluated for various physicochemical properties and all the parameters were found to be within limits. The formulations F1-F9 were formulated and evaluated for various quality control parameters. All the formulations were passed the tests and the results were within limits. From the dissolution data it was evident that formulation F7 was found to be best with maximum percent drug release of 96.90% upto 24 hours.

Keywords: Clarithromycin, HPMCK4M, HPMCK15M, HPMCK100M, Floating tablets.


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