DOI: 10.21276/ajptr
Sun, 21 Jul 2019

Formulation and Evaluation of Decitabine Loaded Niosomes

J.Gomathi 1*, P.Palanisamy1, J.Jayalakshmi1, J.Loganathan1

1.Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, Vinayaka Missions University, Salem-636008 Tamilnadu


Nonionic surfactant vesicles (niosomes) were formulated with an aim of enhancing the oral bioavailability of Decitabine, an anti-cancer drug. Niosomes were formulated by conventional thin film hydration technique with different molar ratios of surfactant, cholesterol and dicetyl phosphate. The formulated niosomes were found spherical in shape, ranging from 2.95 𝜇m to 10.91 𝜇m in size. Vesicles with 1 : 1 : 0.1 ratios of surfactant : cholesterol : dicetyl phosphate with each grade of span were found to have higher entrapment efficiencies, which were further selected for in vitro studies. Vesicles formulated with sorbitan monostearate were found to have maximum drug release (99.091%) at the end of 24 hours and followed zero order release kinetics. In conclusion, noisome could be a promising delivery for Decitabine with improved oral bioavailability and prolonged release profiles.

Keywords:  Niosomes, Decitabine, Non-Ionic Surfactants.

[PDF]   Viewed: 652   Downloaded: 91
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter