Wed, 18 Oct 2017

Development And Evaluation of Colon Specific Drug Delivery System Via pH and Microbial Triggered Mechanism for Colon Cancer

Sardar Shelake1*, Vaibhav Khade2, Pallavi Sangave1, Shitalkumar Patil1

1.Ashokrao Mane College of Pharmacy, Dept. of Pharmaceutics, Peth Vadgaon, 416112,  Kolhapur, Maharashtra, India.

2.KLES’s College of Pharmacy, Department of pharmaceutics, Akkol road, Nipani, Karnataka, India.


ABSTRACT

The assumption on colon-specific drug delivery system suffers from minor inherent problems. The development of novel into pH dependent and microbially triggered compression enteric  coated  tablets  was  done.  Capecitabine was used as a model drug. The core tablet was coated with acid soluble coating, Eudragit®S-100 which was compression coated with immediate release blend of drug containing microbial triggering polysaccharide, guar gum. Different combinations of polymers were selected to achieve drug targeting to the colon for the treatment  of  colorectal cancer. The novel – CODES successfully showed resistance to the gastric environment and exhibited no drug release in simulated intestinal fluid. In-vitro release studies for prepared  tablets  were carried out for 2 hours in 0.1 N HCl, 3 hours in pH 7.4 phosphate buffer and remaining in 6.8 pH phosphate buffer. In vitro studies revealed that it have limited drug release in stomach, small intestine and released maximum drug in the colonic environment.

Keywords: pH dependent, time delayed, microbially triggered, compression coating, CODESTM.


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