DOI: 10.21276/ajptr
Tue, 11 Dec 2018

Development and Validation of UV Spectroscopic Method for Estimation of Albendazole In Tablet Dosage Form

Patil Swapnil R.*, Patil Tejaswini D., Kalpesh V. Sonar

Department of Pharmaceutical Chemistry, Arunamai college of Pharmacy, North Maharashtra University, Mamurabad, Jalgaon (MH), INDIA 425001.


ABSTRACT

Albendazole (ALB), chemically known as methyl [5-(propylthio)-1H-benzimidazol-2-yl] carbamate is widely used as an anthelmintic having a wide spectrum of activity. Numerous numbers of analytical methods are there for the simultaneous estimation of bulk and in formulation, such as spectrophotometry and liquid chromatography. As the UV spectrophotometric method is rapid, simple, accurate and economical, the method has been developed for the assay of the albendazole in pharmaceutical formulation. The wavelengths selected for the method were at 291 nm. The results of analysis have been validated by recovery studies as per ICH guidelines. The developed method was rapid, simple, accurate and economical and it can be used for routine quality control analysis. It showed absorption maxima at 291 nm in analytical grade DMF. The drug obeyed the Beer’s law and showed good correlation of concentration with absorption which reflect in linearity.

Keywords: Albendazole, UV spectrophotometer, Method Development, Method Validation, ICH Guidelines.


[PDF]   Viewed: 333   Downloaded: 100 DOI No: 10.21276/ajptr.2018.08.02.19
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